How long does Plan B stay in your system?

What is Plan B? What is Plan B used for?

Plan B is a brand of ” morning after pill”(which certainly means you shouldn’t wait until morning to take it, it’s best to take it as soon as you can) that contains a synthetic progestational hormone called levonorgestrel. Levonorgestrel is a female hormone that prevents ovulation.

This hormone also causes changes in the lining of the uterine and cervical mucus by making it more difficult for sperm to reach the uterus and for the fertilized egg to become impregnated in the uterus.

Plan B is used to prevent pregnancy after unprotected sex or when other forms of birth control failed, such as condom breakage or lack of 2 or more birth control pills.

To attain the perfect efficacy of the medicine, the first tablet should be taken as soon as possible within 72 hours after sexual intercourse. The second pill should be taken 12 hours later.

How long does Plan B stay in your system?

If you take it in 72 hours following unprotected sexual intercourse, this medicine may decrease your chance of pregnancy by up to 89 percent.

If medications are obtained within 24 hours, then it’s approximately 95% successful. For women under 17, it is only available with a prescription.

For women, over 17 years of age, it is available as OTC, without a prescription. Plan B should never be used for routine use as birth control.

If vomiting, which is a common side effect, occurs within two hours of taking any dose of medication, the dose should be repeated.

Plan B tablet is manufactured as a white round tablet containing 0.75 mg or 1.5 mg of hormone levonorgestrel, marked with the name INOR on one side. Levonorgestrel was synthesized in the 1960s and approved in birth control products since the 1980s.

If medications are taken within 24 hours, it is approximately 95% effective. For women under 17, it is only available with a prescription.

For women over 17 years of age, it is available as OTC, without a prescription. Plan B should never be used for routine use as birth control.

How long does Plan B stay in your system?

If vomiting, which is a common side effect, occurs within two hours of taking any dose of medication, the dose should be repeated.

Plan B tablet is manufactured as a white round tablet containing 0.75 mg or 1.5 mg of hormone levonorgestrel, marked with the name INOR on one side. Levonorgestrel was synthesized in the 1960s and approved in birth control products since the 1980s.

If medications are taken within 24 hours, it is approximately 95% effective. For women under 17, it is only available with a prescription. For women over 17 years of age, it is available as OTC, without a prescription.

Plan B should never be used for routine use as birth control. If vomiting, which is a common side effect, occurs within two hours of taking any dose of medication, the dose should be repeated.

Plan B tablet is manufactured as a white round tablet containing 0.75 mg or 1.5 mg of hormone levonorgestrel, marked with the name INOR on one side. Levonorgestrel was synthesized in the 1960s and approved in birth control products since the 1980s. Plan B should never be used for routine use as birth control.

If vomiting, which is a common side effect, occurs within two hours of taking any dose of medication, the dose should be repeated. Plan B tablet is manufactured as a white round tablet containing 0.75 mg or 1.5 mg of hormone levonorgestrel, marked with the name INOR on one side.

Levonorgestrel was synthesized in the 1960s and approved in birth control products since the 1980s. Plan B should never be used for routine use as birth control.

If vomiting, which is a common side effect, occurs within two hours of taking any dose of medication, the dose should be repeated.

Plan B tablet is manufactured as a white round tablet containing 0.75 mg or 1.5 mg of hormone levonorgestrel, marked with the name INOR on one side. Levonorgestrel was synthesized in the 1960s and approved in birth control products since the 1980s.

How does plan B work in the body?

How long does Plan B stay in your system?

Levonorgestrel, an active ingredient in Plan B, is a synthetic form of the female sex hormone that is produced naturally called progesterone. During the menstrual cycle, a mature egg and the ovaries release the egg.

After that, the ovary produces progesterone, preventing the release of more eggs and preparing the lining of the uterus for a possible pregnancy.

If pregnancy occurs, the body produces progesterone in large amounts, maintaining the lining of the uterus.

If pregnancy does not occur, progesterone levels decrease, resulting in a menstrual period. Levonorgestrel works by deceiving normal body processes by making ovulation already occur and maintaining high levels of synthetic progesterone. This results in preventing egg release from the ovaries.

Regarding Pharmacology, levonorgestrel works by joining progesterone and estrogen receptors. Target cells are located in the female reproductive tract, hypothalamus, mammary gland, and pituitary gland.

Once bound to the receptor, the levonorgestrel decreases the frequency of release of gonadotropin-releasing hormone (GnRH) from the hypothalamus and blunt the luteinizing hormone before ovulation: increase LH.

How long do Plan B hormones (the morning after pill) remain in your system? Blood, breast milk, urine, saliva, hair

The elimination half-life time of levonorgestrel is estimated at 24.4 hours + / – 5.3 hours. This means that 50% of the administered drug will be removed from the body for about a day after ingestion.

So, If the Half-Life Time is 24.4 hours, then it can be estimated that it might take about 5.6 days to eliminate just one dose of Plan B in the bloodstream.

But some findings have shown that there is a 5.3-hour deviation among many users. This means that some women may exhibit elimination half-lives of almost 19 hours, while others may exhibit half-lives of almost 30 hours.

Therefore, women with faster half-lives of elimination could remove Plan B from their systems in 4.4 days, while those with slower half-lives of elimination could consume this medication in 6.8 days. In general,

What factors can influence how long does Plan B stay in your system?

Many factors can have an impact on removing methadone from the body. These factors may include:

A dose took Plan B

The higher dose of Plan B is taken, the longer it takes to remove levonorgestrel from the body system.

The results showed that when taking levonorgestrel in low doses, such as from 0.15 mg to 0.25 mg, the elimination half-life of levonorgestrel is significantly reduced in comparison with the standard dose of 0.75 mg, The half-lives of doses of 0.15 mg and 0.25 mg were estimated in a range of 9.9 to 13.2 hours, respectively.

Body mass index-BMI and body fat percentage

How long does Plan B stay in your system?

Levonorgestrel is highly lipophilic because it contains a cholesterol-like structure, which means it is likely to be fat-soluble. Therefore, it is common to accumulate among obese or those with a high percentage of body fat, especially when given more frequently than consumption.

Genetic

Although researchers suggested that the polymorphisms of the CYP3A4 * 1B and CYP3A5 * 3 genes may alter the metabolism and elimination of levonorgestrel, there is no real evidence to support this theory.

Hepatic function

Women with hepatic impairment as a result of a condition such as cirrhosis will not be able to efficiently metabolize levonorgestrel. Reduced metabolism of levonorgestrel is likely to increase plasma concentrations and prolong elimination after administration.

Renal function

Levonorgestrel is excreted mainly through the kidneys. Those with the compromised renal function may retain levonorgestrel metabolites in the body for longer than normal.

Renal impairment may cause the accumulation of medicines before elimination, which may contribute to the reabsorption and redistribution of the medicine throughout the body.

Concomitant use of other drugs or substances

Levonorgestrel is metabolized by CYP3A4 and CYP1A2 isoenzymes in the liver. Inhibitors of these isoenzymes such as ritonavir and fluvoxamine may increase the risk of the drug remaining longer in the body due to reduced metabolism.

On the other hand, inducers of the same isoenzymes, such as Modafinil or tobacco, can accelerate levonorgestrel metabolism and lead to faster elimination.

Side effects of Plan B

Although Plan B is incredibly useful, it can cause unwanted side effects very often, such as headaches, breast tenderness, menstrual irregularities, and nausea.

Plan B may cause the following side effects with the following incidence::

  • A headache (12%)
  • Acne (15%)
  • Ovarian cysts (13%)
  • Enlarged follicles (12%)
  • Amenorrhea (1-12%)
  • Abdominal pain (12%)
  • Uterine / vaginal bleeding disorders (52%)
  • Bleeding/spotting (23%)
  • Vulvovaginitis (20%)
  • Ectopic pregnancy (≤50%)
  • Depression (4%)
  • A migraine (2%)
  • Alopecia (1%)
  • Dysmenorrhea (9%)
  • Menorrhagia (6%)
  • Breast tenderness (3-9%)
  • Pelvic pain (6%)
  • Leucorrhea (5%)
  • Vaginal discharge (4%)
  • Pelvic infection (1%)
  • Angioedema (<1%)
  • Drill cervical (<1%)
  • Insertion failed (<1%)
  • Sepsis (<1%)
  • Uterine bleeding (<1%)
  • Breakage of the device (<1%)