What is Hydrocodone? What is Its Use?
Hydrocodone is a generic name for an opioid analgesic drug. Chemically hydrocodone is also known as dihydrocodeinone. It is a semi-synthetic opioid medicine that is synthesized from codeine.
Hysingla ER and Zohydro ER are long-acting forms of hydrocodone that are used for permanent treatment for the treatment of moderate to severe pain.
The prolonged release form of hydrocodone is not to be used as needed for pain. Hydrocodone is also commonly used in liquid form as an antitussive/antitussive.
How does Hydrocodone work?
Hydrocodone works as an opioid agonist for opioid receptors in the brain. This medication blocks the perception of pain in the cerebral cortex of the brain. Hydrocodone reduces synaptic chemical transmission in the brain, which then inhibits the sensation of pain in the higher centers of the brain.
The agonist actions in the μ and k receptors cause analgesia, a decrease in body temperature and miosis. The agonist activity in the μ receptor may also cause the suppression of opioid withdrawal, while the antagonist activity may result in the precipitation of abstinence.
Hydrocodone acts in several areas within the brain by involving several neurotransmitter systems to relieve pain, but the precise mechanism has not yet been fully understood.
Side effects of Hydrocodone
Common side effects of hydrocodone that usually do not require medical attention include:
Side effects that patients should report to their doctor or health professional as soon as possible since they can be severe include:
- shortness of breath, wheezing
- allergic reactions such as rash, itching or hives, swelling of the face, lips or tongue
- light dizziness or fainting
How long does hydrocodone last in your system?
Studies have shown that the half-life of elimination of hydrocodone is an average of 3.8 hours. This means that your body will take less than 4 hours to excrete 50% of the dose of hydrocodone administered. This means that the body will excrete hydrocodone from its system for 20.9 hours.
However, other findings suggest that there could be a greater difference in the half-life of drugs, which ranges from 3.3 hours to 4.1 hours.
This indicates that some patients can eliminate the drug much faster during 18.15 hours, while others may have a prolonged systemic time of elimination with 22.55 hours. In most patients, hydrocodone must be eliminated from the body in 1 day. However, it may not eliminate the active metabolite of hydrocodone, called norhydrocodone, for up to 2 days.
Many factors can influence the time that hydrocodone and its active metabolites will remain in your system. These factors can be internal or individual, such as age, genetics, body mass, liver and kidney function, etc. External factors such as the frequency of hydrocodone use and other medications are taken at the same time may also have an influence.
How long does hydrocodone last in your Urine
It depends on the test used. A urine test with three drugs usually just checks the presence of marijuana, cocaine, and meth. If they check the hydrocodone, it usually leaves your system after three days, if you do not take them every day, then they stay for about two weeks.
The best thing you can do if you are worried about failure is to go to the emergency room and tell them that you have hurt your back and they will either give you a hydrocodone or a slice with enough to last a couple of days, after which you will be good. Because they are prescribed to you.
How long does hydrocodone last in your blood?
In typical situations, hydrocodone should be detectable in the blood for one day after the last dose is administered.
How long does hydrocodone last in your hair?
Hydrocodone can be detected in hair up to 90 days.
How long does hydrocodone last in your saliva?
In saliva, hydrocodone can be detected up to 1 day after administration, while norhydrocodone can remain detectable for up to 2 days.
How long will Hydrocodone last in your system if you inhale it?
If hydrocodone is inhaled, it will pass into your system more quickly than after ingestion. There is no time to waste in the absorption of the drug.
The effects are almost immediate. Depending on the amount of hydrocodone taken, it will remain approximately in the body for 12-24 hours after administration.
How does age affect the elimination of hydrocodone?
The elderly (over 65) compared to younger individuals often metabolize and eliminate medications at much slower rates. Your organs such as the liver or kidneys may have a lower function, and your internal blood flow is reduced to the liver.
Also, the elderly often take many other medications, and some of them may delay the metabolism or excretion of hydrocodone.
How height/ weight/body fat affects the elimination of hydrocodone?
The patient’s height, weight, and amount of fat can influence how quickly the body removes the medication from the system.
In theory, the taller and heavier patients should eliminate 5 mg of hydrocodone faster compared to the shorter and lighter individuals. This is because the lower the dose of the drug given to its height/weight, the faster the elimination, vice versa also applies.
How genetics affects the elimination of hydrocodone?
It is known that different genes influence the metabolism of drugs, including hydrocodone. Genes that regulate hepatic CYP450 enzymes such as CYP2D6 can be very influential if a patient metabolizes hydrocodone at a faster or slower rate than the average.
Based on genetics, individual patients are classified as “fast metabolizers”, while others are “slow metabolizers”. This can result in different effects of medications, but also variability in elimination rates.
How does the elimination of hydrocodone affect food?
Foods such as carbohydrates can slow down the absorption of hydrocodone if taken together. However, taking hydrocodone on an empty stomach may increase the intake of this medication.
The differences in absorption time could influence the speed of elimination of the drug from the body. Those who ingest a high-carbohydrate meal along with hydrocodone, the removal may be delayed.
How does liver or kidney function affect the elimination of hydrocodone?
Since hydrocodone is Later in the liver, liver problems and impaired hepatic function can prolong the half-life and prolong the elimination of hydrocodone.
For example, someone with cirrhosis or hepatitis may take hours more to metabolize and eliminate hydrocodone from their system compared to healthy people. Also, kidney failure can also delay the elimination of the medication.
How does urinary pH affect the elimination of hydrocodone?
Patients with more acid urine can eliminate hydrocodone and frequently used it more effectively than those with highly alkaline urine. It is known that the alkalinity of the urine promotes the re-absorption of the drug before its elimination and, therefore, slows down the clearance.
withdrawal symptoms of hydrocodone
Whenever someone is now addicted to an opioid medication like hydrocodone, the elimination of it can result in a painful experience since the human body and mind have an overdrive condition hoping to recuperate.
You should not stop taking hydrocodone suddenly without consulting with your physician since you could have serious withdrawal symptoms. These can include:
- enlarged students
- muscle cramps
- joint pain
- rapid breathing
- rapid heartbeat
- A runny nose
- Watering eyes
- Sleep difficulty
- Issue focusing
- High blood pressure
- Intense cravings
- Suicidal thoughts
Your physician may lower your dosage slowly over time to stop withdrawal. This can be called tapering. It is suggested that the dose is decreased gradually, by a 25 to 50 percent each two to four times, while tracking carefully for symptoms and signs of withdrawal.
Hydrocodone withdrawal timeline
First 48 hours
|Symptoms begin to arise within the first day with no hydrocodone. Among the primary symptoms is generally aching in the muscles, bones or joints. In this amount of your time, some individuals nowadays expertise nausea, abdominal cramping, and perspiration.|
|Since the body adjusts to life while not hydrocodone, withdrawal symptoms can summit. In this time period, the entire body expels toxins through nausea, diarrhea, and excess perspiration. Some people today experience vibration and lingering muscular aches.|
|Stress, depression and a want to return back to the medication will all seem at the conclusion of withdrawal. Former addicts whose heads have started to clear frequently feel shame and guilt for things that they did and said.|
|Based upon the individual, emotional withdrawal symptoms, such as stress, can linger for a month or more after stopping use.|
Is hydrocodone water soluble or fat soluble?
Later. Opiates are very soluble in water if they are not in their free form, but hydrocodone is not in its free form, so it is water-soluble.
Acetaminophen (Tylenol), ibuprofen, aspirin are only very slightly soluble in water and are practically insoluble at low temperatures.
Which color of hydrocodone syrup is the strongest?
Yellow (Tussionex 10 mg hydrocodone) * Strongest
Red (Hydromet 5 mg hydrocodone)
-Here is the catch, yellow has 10 mg of hydrocodone, but for a long time, so it is released slowly, and it did not hit you quickly.
Red has only 5 mg of hydrocodone but is instantaneously released, so it has a rapid onset. Although less powerful
Combination of these facts Yellow and red are approximately equal in their effects, and each of them is strong in its way. So, you get one of these colors that you have, what you do. I tried both, and I would go with the yellow one.
– knowing that the yellow color is weaker and the red color is higher due to the unperforated ingredients that the two syrups differ from each other
How does the frequency of Hydrocodone use affect its elimination?
Users of a single dose (patients who use hydrocodone-only once) are more likely to eliminate the drug faster from the body than those who use it regularly for a prolonged period.
This is likely to be caused by the fact that when hydrocodone is frequently used for several days, hydrocodone and its metabolites will accumulate in the body until the “peak” is reached. Once the “peak” is reached, the cleaning time will be extended.
Single and infrequent users will probably accumulate hydrocodone compared to frequent users. Such patients should be able to excrete the drug efficiently from the body in less than two days.
However, long-term users who are being treated with chronic hydrocodone may take more than two days to eliminate hydrocodone.
How other medications affect the elimination of hydrocodone?
Because hydrocodone is metabolized by the cytochrome 450 CYP2D6 isoenzyme, all drugs that affect CYP2D6 can reduce or prolong the half-life of hydrocodone. It is known that drugs classified as CYP2D6 inhibitors affect the body’s ability to eliminate hydrocodone from the body.
The CYP2D6 inhibitors are SSRI medications (such as paroxetine, citalopram, fluoxetine, etc.), codeine, methadone, amiodarone, sertindole, yohimbine, and more. Specific inhibitors of CYP2D6 can slow down metabolism to a higher degree than others, and dosing often plays a role.
There are also drugs known as “inducers” of CYP2D6, such as dexamethasone and rifampin, which can improve the metabolism of hydrocodone. These medications enhance the metabolism of hydrocodone,